Acidity regulators in food: types, functions, and health impact

Acidity regulators, also known as pH control agents, are additives used in processed foods to modify or stabilize their acidity or alkalinity, which is measured by their pH value. Their function often overlaps with that of other food additives: some can also act as preservatives, others as emulsifiers, while some help preserve the color of the food to which they are added. In this way, they contribute, along with other factors, to maintaining or improving the organoleptic properties of the product.[1][2]

Like other food additives, acidity regulators are identified both by their chemical name and by the E-numbering system, where ‘E’ stands for Europe.[3]

According to the scientific evidence currently available, when used in accordance with specific guidelines, acidity regulators are not harmful to human health.[4][5]

Contents

What they are used for

Acidity regulators are employed in a wide range of foods. Their main functions are outlined below.

  • pH stabilization.
    Some foods require an acidic or neutral environment to maintain their chemical integrity and, consequently, their organoleptic properties. For example, carbonated drinks need acids to prevent changes in taste and composition during storage.
  • Food preservation.
    Acidity helps prevent the growth of harmful microorganisms such as bacteria and mold. This is particularly important in packaged foods and preserves, where a low pH acts as a natural barrier against microbial growth. In this way, acidity regulators can function as preservatives.
  • Flavor enhancement.
    Acidity regulators can balance flavors by adding a sour note that enhances the overall taste. For instance, lactic acid (E270) is used in dairy products and fermented foods to improve flavor.
  • Support for consistency and quality.
    By regulating acidity, these additives can help stabilize the structure of certain foods, such as cheeses, sweets, and ice cream, acting in a way similar to emulsifiers.
  • Enhancement of antioxidant action.
    Some acidity regulators, such as citric acid (E330), though not antioxidants themselves, can enhance the activity of other antioxidants.[1][2][6][7]

Examples of acidity regulators

Below is an overview of some acidity regulators included in the list of food additives authorized for use in the European Union under Regulation (EU) No. 1129/2011 of the European Commission, published on November 11, 2011. This list, which amended Annex II of Regulation (EC) No. 1333/2008 of the European Parliament, was later revised in 2013.[8]

List of acidity regulators with their E-numbers and chemical names.
E-number Additive and derivatives
Acetic acid and its salts
E260 Acetic acid
E261 Potassium acetate
E262 Sodium acetate
E263 Calcium acetate
Lactic acid and its salts
E270 Lactic acid
E325 Sodium lactate
E326 Potassium lactate
E327 Calcium lactate
Citric acid and its salts
E330 Citric acid
E331 Sodium citrate
E332 Potassium citrate
E333 Calcium citrate
E380 Triammonium citrate
Tartaric acid and its salts
E334 L-(+)-Tartaric acid
E335 Sodium tartrate
E336 Potassium tartrate
E337 Sodium potassium tartrate
E353 Metatartaric acid
E354 Calcium tartrate
Malic acid and its salts
E296 Malic acid
E350 Sodium malate
E351 Potassium malate
E352 Calcium malate

Health effects

As with other food additives, the safety of acidity regulators is evaluated by the competent authorities on the basis of the scientific literature available at the time of the assessment.[4]
Skeletal formulas of acidity regulators used in food, such as acetic acid, lactic acid, malic acid, citric acid, L-(+)-tartaric acid, and metatartaric acid.According to current scientific evidence, when used in accordance with regulations, acidity regulators such as acetic acid (E 260), lactic acid, citric acid and tartaric acid (E 334–337, E 354) have not been associated with adverse health effects at permitted use levels. A 2020 EFSA Panel evaluation found no safety concerns for these compounds at the reported use concentrations.[7]

However, like all additives, they remain subject to periodic safety reassessments.[5][9]

References

  1. ^ a b Damodaran S., Parkin K. Fennema’s Food Chemistry. 5th Edition. CRC Press, 2017.doi:10.1201/9781315372914
  2. ^ a b EUFIC What are acidity regulators and why are they added to food. Last Updated: 01 December 2021. https://www.eufic.org/en/whats-in-food/article/acidity-regulators-the-multi-task-players
  3. ^ Food Standards Agency. Approved additives and E Numbers. Last updated: 16 July 2025.
  4. ^ a b Bailey R.L. Current regulatory guidelines and resources to support research of dietary supplements in the United States. Crit Rev Food Sci Nutr 2020;60(2):298-309. doi:10.1080/10408398.2018.1524364
  5. ^ a b EFSA Food additives: EFSA’s new guidance for applicants. Published: 18 July 2012. https://www.efsa.europa.eu/en/press/news/120718a
  6. ^ Belitz H.-D., Grosch W., Schieberle P. Food Chemistry. 4th Edition. Springer, 2009.
  7. ^ a b EFSA FAF Panel (EFSA Panel on Food Additives and Flavourings), Younes M., Aquilina G., Castle L., et al. Scientific opinion on the re-evaluation of acetic acid, lactic acid, citric acid, tartaric acid, mono- and diacetyltartaric acid, mixed acetic and tartaric acid esters of mono- and diglycerides of fatty acids (E 472a-f) as food additives. EFSA Journal 2020;18(3):6032, 66 pp. doi:10.2903/j.efsa.2020.6032
  8. ^ Commission Regulation (EU) No 1129/2011 of 11 November 2011 amending Annex II to Regulation (EC) No 1333/2008 of the European Parliament and of the Council by establishing a Union list of food additives. https://eur-lex.europa.eu/eli/reg/2011/1129/2013-11-21
  9. ^ EFSA Food additives. Last reviewed date: 18 July 2025.

Biochemistry and Metabolism