The pentose phosphate pathway

CONTENTS What is the pentose phosphate pathway? The elucidation of the pentose phosphate pathway Functions of NADPH and ribose 5-phosphate Where does the pentose phosphate pathway occur? The two phases of the pentose phosphate pathway The steps of the oxidative phase of the pentose phosphate pathway The oxidation of glucose 6-phosphate to 6-phosphoglucono-δ-lactone Catalytic mechanism […]

Glycolysis

CONTENTS What is glycolysis? Glycolysis: the first metabolic pathway to be elucidated Why is glycolysis so important? The steps of glycolysis Reaction 1: glucose phosphorylation to glucose 6-phosphate The importance of glucose phosphorylation Other possible fates of glucose 6-phosphate Reaction 2: isomerization of glucose 6-phosphate to fructose 6-phosphate Reaction 3: phosphorylation of fructose 6-phosphate to […]

Gluconeogenesis

CONTENTS What is gluconeogenesis? Why is gluconeogenesis important? Where does gluconeogenesis occur? Irreversible steps of gluconeogenesis From pyruvate to phosphoenolpyruvate Phosphoenolpyruvate precursor: pyruvate or alanine Phosphoenolpyruvate precursor: lactate From fructose 1,6-bisphosphate to fructose 6-phosphate From glucose 6-phosphate to glucose Gluconeogenesis: energetically expensive Coordinated regulation of gluconeogenesis and glycolysis Regulation of gluconeogenesis Pyruvate carboxylase Fructose 1,6-bisphosphatase […]

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